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Target-based evaluation of ‘drug-like’ properties and ligand efficiencies
Physicochemical descriptors commonly used to define ‘drug-likeness’, and ligand efficiency measures, are assessed for their ability to differentiate marketed drugs from compounds reported to bind to their efficacious target or targets. Using ChEMBL version 26, a dataset of 643 drugs acting on 271 ta...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610969/ https://www.ncbi.nlm.nih.gov/pubmed/33983732 http://dx.doi.org/10.1021/acs.jmedchem.1c00416 |