Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma

Immune checkpoint blockade (ICB) of PD-1 and CTLA-4 to treat metastatic melanoma (MM) has variable therapeutic benefit. To explore this in peripheral samples we characterized CD8(+) T cell gene expression across a cohort of MM patients receiving anti-PD-1 alone (sICB) or in combination with anti-CTL...

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Detalles Bibliográficos
Autores principales: Fairfax, Benjamin P, Taylor, Chelsea A, Watson, Robert A, Nassiri, Isar, Danielli, Sara, Fang, Hai, Mahé, Elise A, Cooper, Rosalin, Woodcock, Victoria, Traill, Zoe, Al-Mossawi, M Hussein, Knight, Julian C, Klenerman, Paul, Payne, Miranda, Middleton, Mark R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611047/
https://www.ncbi.nlm.nih.gov/pubmed/32042196
http://dx.doi.org/10.1038/s41591-019-0734-6

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