Skin and gut imprinted T helper cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity

Multidimensional single cell-analyses of T cells have fueled the debate about either extensive plasticity or “mixed” priming of T helper cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant o...

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Detalles Bibliográficos
Autores principales: Hiltensperger, Michael, Beltrán, Eduardo, Kant, Ravi, Tyystjärvi, Sofia, Lepennetier, Gildas, Moreno, Helena Domínguez, Bauer, Isabel J., Grassmann, Simon, Jarosch, Sebastian, Schober, Kilian, Buchholz, Veit R., Kenet, Selin, Gasperi, Christiane, Öllinger, Rupert, Rad, Roland, Muschaweckh, Andreas, Sie, Christopher, Aly, Lilian, Knier, Benjamin, Garg, Garima, Afzali, Ali M., Gerdes, Lisa Ann, Kümpfel, Tania, Franzenburg, Sören, Kawakami, Naoto, Hemmer, Bernhard, Busch, Dirk H., Misgeld, Thomas, Dornmair, Klaus, Korn, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611097/
https://www.ncbi.nlm.nih.gov/pubmed/34099917
http://dx.doi.org/10.1038/s41590-021-00948-8

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