A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

The ability of gut bacterial pathogens to escape immunity by antigenic variation, particularly via changes to surface-exposed antigens, is a major barrier to immune clearance(1). However, not all variants are equally fit in all environments(2,3). It should therefore be possible to exploit such immun...

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Detalles Bibliográficos
Autores principales: Diard, Médéric, Bakkeren, Erik, Lentsch, Verena, Rocker, Andrea, Bekele, Nahimi Amare, Hoces, Daniel, Aslani, Selma, Arnoldini, Markus, Böhi, Flurina, Schumann-Moor, Kathrin, Adamcik, Jozef, Piccoli, Luca, Lanzavecchia, Antonio, Stadtmueller, Beth M., Donohue, Nicholas, van der Woude, Marjan W., Hockenberry, Alyson, Viollier, Patrick H., Falquet, Laurent, Wüthrich, Daniel, Bonfiglio, Ferdinando, Loverdo, Claude, Egli, Adrian, Zandomeneghi, Giorgia, Mezzenga, Raffaele, Holst, Otto, Meier, Beat H., Hardt, Wolf-Dietrich, Slack, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611113/
https://www.ncbi.nlm.nih.gov/pubmed/34045711
http://dx.doi.org/10.1038/s41564-021-00911-1

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