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An interdependent network of functional enhancers regulates transcription and EZH2 loading at the INK4a/ARF locus

The INK4a/ARF locus encodes important cell-cycle regulators p14(ARF), p15(INK4b), and p16(INK4a). The neighboring gene desert to this locus is the most reproducible GWAS hotspot that harbors one of the densest enhancer clusters in the genome. However, how multiple enhancers that overlap with GWAS va...

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Detalles Bibliográficos
Autores principales:	Farooq, Umer, Saravanan, Bharath, Islam, Zubairul, Walavalkar, Kaivalya, Singh, Anurag Kumar, Jayani, Ranveer Singh, Meel, Sweety, Swaminathan, Sudha, Notani, Dimple
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611173/ https://www.ncbi.nlm.nih.gov/pubmed/33761351 http://dx.doi.org/10.1016/j.celrep.2021.108898

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