Impact of SARS‐CoV‐2 on multiple gestation pregnancy

OBJECTIVE: To assess clinical presentations, pregnancy complications, and maternal and neonatal outcomes among women with multiple gestation pregnancy (MGP) and confirmed SARS‐CoV‐2 (COVID‐19) infection and to compare the data with a pre‐pandemic period. METHODS: A retrospective study at a dedicated COVID‐19 Hospital in Mumbai, India. Data were obtained from the PregCovid Registry of pregnant and postpartum women with PCR‐confirmed SARS‐CoV‐2 infection from April to September, 2020. Data were also compared with a cohort of women with MGP attending the hospital pre‐pandemic (n = 63). RESULTS: Data from 879 women (singleton pregnancy, n = 859; MGP, n = 20) with COVID‐19 were assessed. The twinning rate was 34.2 per 1000 births. As compared with singleton pregnancies, a higher proportion of women with MGP and Covid‐19 delivered preterm (P = 0.001). Spontaneous abortions were also higher in the MGP group than in the singleton group (P = 0.055). The incidence of pre‐eclampsia/eclampsia was higher in the COVID‐19 MGP group than in both the COVID‐19 singleton (41.6% vs. 7.9%) and pre‐pandemic MGP (50.0% vs. 12.7%) groups. CONCLUSION: There was a higher risk of pre‐eclampsia among women with MGP and COVID‐19. Women with MGP and COVID‐19 infection should receive special attention with a multidisciplinary approach to both maternal and neonatal care during the pandemic.