Photoactivated release of membrane impermeant sulfonates inside cells

Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradi...

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Detalles Bibliográficos
Autores principales: Caldwell, Stuart T., O'Byrne, Sean N., Wilson, Calum, Cvetko, Filip, Murphy, Michael P., McCarron, John G., Hartley, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611313/
https://www.ncbi.nlm.nih.gov/pubmed/33871501
http://dx.doi.org/10.1039/d0cc07713e
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author Caldwell, Stuart T.
O'Byrne, Sean N.
Wilson, Calum
Cvetko, Filip
Murphy, Michael P.
McCarron, John G.
Hartley, Richard C.
author_facet Caldwell, Stuart T.
O'Byrne, Sean N.
Wilson, Calum
Cvetko, Filip
Murphy, Michael P.
McCarron, John G.
Hartley, Richard C.
author_sort Caldwell, Stuart T.
collection PubMed
description Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.
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spelling pubmed-76113132021-07-19 Photoactivated release of membrane impermeant sulfonates inside cells Caldwell, Stuart T. O'Byrne, Sean N. Wilson, Calum Cvetko, Filip Murphy, Michael P. McCarron, John G. Hartley, Richard C. Chem Commun (Camb) Chemistry Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell. The Royal Society of Chemistry 2021-03-12 /pmc/articles/PMC7611313/ /pubmed/33871501 http://dx.doi.org/10.1039/d0cc07713e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Caldwell, Stuart T.
O'Byrne, Sean N.
Wilson, Calum
Cvetko, Filip
Murphy, Michael P.
McCarron, John G.
Hartley, Richard C.
Photoactivated release of membrane impermeant sulfonates inside cells
title Photoactivated release of membrane impermeant sulfonates inside cells
title_full Photoactivated release of membrane impermeant sulfonates inside cells
title_fullStr Photoactivated release of membrane impermeant sulfonates inside cells
title_full_unstemmed Photoactivated release of membrane impermeant sulfonates inside cells
title_short Photoactivated release of membrane impermeant sulfonates inside cells
title_sort photoactivated release of membrane impermeant sulfonates inside cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611313/
https://www.ncbi.nlm.nih.gov/pubmed/33871501
http://dx.doi.org/10.1039/d0cc07713e
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