IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer

The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated. In our study we could demonstrate for the first time a positive prognosti...

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Detalles Bibliográficos
Autores principales: Droeser, Raoul André, Iezzi, Giandomenica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611329/
https://www.ncbi.nlm.nih.gov/pubmed/34296212
http://dx.doi.org/10.33696/immunology.3.087
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author Droeser, Raoul André
Iezzi, Giandomenica
author_facet Droeser, Raoul André
Iezzi, Giandomenica
author_sort Droeser, Raoul André
collection PubMed
description The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated. In our study we could demonstrate for the first time a positive prognostic role of interleukin-22 in human colorectal cancer relying on its capacity to induce in tumor cells the production of chemokines recruiting into the tumor microenvironment neutrophils associated with a favorable clinical outcome.
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spelling pubmed-76113292021-07-21 IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer Droeser, Raoul André Iezzi, Giandomenica J Cell Immunol Article The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated. In our study we could demonstrate for the first time a positive prognostic role of interleukin-22 in human colorectal cancer relying on its capacity to induce in tumor cells the production of chemokines recruiting into the tumor microenvironment neutrophils associated with a favorable clinical outcome. 2021 /pmc/articles/PMC7611329/ /pubmed/34296212 http://dx.doi.org/10.33696/immunology.3.087 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Droeser, Raoul André
Iezzi, Giandomenica
IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
title IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
title_full IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
title_fullStr IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
title_full_unstemmed IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
title_short IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
title_sort il-22-mediates cross-talk between tumor cells and immune cells associated with favorable prognosis in human colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611329/
https://www.ncbi.nlm.nih.gov/pubmed/34296212
http://dx.doi.org/10.33696/immunology.3.087
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