SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation

Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation(1). Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites(2), improving insulin sensitivity(3) or promoting an immune tolerant m...

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Detalles Bibliográficos
Autores principales: Bidault, Guillaume, Virtue, Samuel, Petkevicius, Kasparas, Jolin, Helen E., Dugourd, Aurélien, Guénantin, Anne-Claire, Leggat, Jennifer, Mahler-Araujo, Betania, Lam, Brian Y.H., Ma, Marcella K., Dale, Martin, Carobbio, Stefania, Kaser, Arthur, Fallon, Padraic G., Saez-Rodriguez, Julio, McKenzie, Andrew N.J., Vidal-Puig, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611716/
https://www.ncbi.nlm.nih.gov/pubmed/34531575
http://dx.doi.org/10.1038/s42255-021-00440-5

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