HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

HUWE1 is a universal quality-control E3 ligase that marks diverse client proteins for proteasomal degradation. Although the giant HECT enzyme is an essential component of the ubiquitin-proteasome system closely linked with severe human diseases, its molecular mechanism is little understood. Here, we...

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Detalles Bibliográficos
Autores principales: Grabarczyk, Daniel B, Petrova, Olga A, Deszcz, Luiza, Kurzbauer, Robert, Murphy, Paul, Ahel, Juraj, Vogel, Antonia, Gogova, Rebeca, Faas, Victoria, Kordic, Darja, Schleiffer, Alexander, Meinhart, Anton, Imre, Richard, Lehner, Anita, Neuhold, Jana, Bader, Gerd, Stolt-Bergner, Peggy, Böttcher, Jark, Wolkerstorfer, Bernhard, Fischer, Gerhard, Grishkovskaya, Irina, Haselbach, David, Kessler, Dirk, Clausen, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611724/
https://www.ncbi.nlm.nih.gov/pubmed/34294896
http://dx.doi.org/10.1038/s41589-021-00831-5

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