Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors

The nuclear pore complex (NPC) forms a permeability barrier between the nucleus and the cytoplasm. Molecules that are able to cross this permeability barrier encounter different disordered phenylalanine glycine rich nucleoporins (FG-Nups) that act as a molecular filter and regulate the selective NPC...

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Detalles Bibliográficos
Autores principales: Aramburu, Iker Valle, Lemke, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611744/
https://www.ncbi.nlm.nih.gov/pubmed/28669824
http://dx.doi.org/10.1016/j.semcdb.2017.06.026
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author Aramburu, Iker Valle
Lemke, Edward A.
author_facet Aramburu, Iker Valle
Lemke, Edward A.
author_sort Aramburu, Iker Valle
collection PubMed
description The nuclear pore complex (NPC) forms a permeability barrier between the nucleus and the cytoplasm. Molecules that are able to cross this permeability barrier encounter different disordered phenylalanine glycine rich nucleoporins (FG-Nups) that act as a molecular filter and regulate the selective NPC crossing of biomolecules. In this review, we provide a current overview regarding the interaction mechanism between FG-Nups and the carrier molecules that recognize and enable the transport of cargoes through the NPC aiming to understand the general molecular mechanisms that facilitate the nucleocytoplasmic transport.
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spelling pubmed-76117442021-09-29 Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors Aramburu, Iker Valle Lemke, Edward A. Semin Cell Dev Biol Article The nuclear pore complex (NPC) forms a permeability barrier between the nucleus and the cytoplasm. Molecules that are able to cross this permeability barrier encounter different disordered phenylalanine glycine rich nucleoporins (FG-Nups) that act as a molecular filter and regulate the selective NPC crossing of biomolecules. In this review, we provide a current overview regarding the interaction mechanism between FG-Nups and the carrier molecules that recognize and enable the transport of cargoes through the NPC aiming to understand the general molecular mechanisms that facilitate the nucleocytoplasmic transport. 2017-08-01 2017-06-30 /pmc/articles/PMC7611744/ /pubmed/28669824 http://dx.doi.org/10.1016/j.semcdb.2017.06.026 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Aramburu, Iker Valle
Lemke, Edward A.
Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors
title Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors
title_full Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors
title_fullStr Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors
title_full_unstemmed Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors
title_short Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors
title_sort floppy but not sloppy: interaction mechanism of fg-nucleoporins and nuclear transport receptors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611744/
https://www.ncbi.nlm.nih.gov/pubmed/28669824
http://dx.doi.org/10.1016/j.semcdb.2017.06.026
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