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The SLC25 Mitochondrial Carrier Family: Structure and Mechanism

Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mitochondrial inner membrane and are crucial for many cellular processes. Here, we use new insights into the transport...

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Detalles Bibliográficos
Autores principales: Ruprecht, Jonathan J., Kunji, Edmund R.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611774/
https://www.ncbi.nlm.nih.gov/pubmed/31787485
http://dx.doi.org/10.1016/j.tibs.2019.11.001
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author Ruprecht, Jonathan J.
Kunji, Edmund R.S.
author_facet Ruprecht, Jonathan J.
Kunji, Edmund R.S.
author_sort Ruprecht, Jonathan J.
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description Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mitochondrial inner membrane and are crucial for many cellular processes. Here, we use new insights into the transport mechanism of the mitochondrial ADP/ATP carrier to examine the structure and function of other mitochondrial carriers. They all have a single substrate-binding site and two gates, which are present on either side of the membrane and involve salt-bridge networks. Transport is likely to occur by a common mechanism, in which the coordinated movement of six structural elements leads to the alternating opening and closing of the matrix or cytoplasmic side of the carriers.
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spelling pubmed-76117742021-10-06 The SLC25 Mitochondrial Carrier Family: Structure and Mechanism Ruprecht, Jonathan J. Kunji, Edmund R.S. Trends Biochem Sci Article Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mitochondrial inner membrane and are crucial for many cellular processes. Here, we use new insights into the transport mechanism of the mitochondrial ADP/ATP carrier to examine the structure and function of other mitochondrial carriers. They all have a single substrate-binding site and two gates, which are present on either side of the membrane and involve salt-bridge networks. Transport is likely to occur by a common mechanism, in which the coordinated movement of six structural elements leads to the alternating opening and closing of the matrix or cytoplasmic side of the carriers. 2020-03-01 2019-11-29 /pmc/articles/PMC7611774/ /pubmed/31787485 http://dx.doi.org/10.1016/j.tibs.2019.11.001 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Ruprecht, Jonathan J.
Kunji, Edmund R.S.
The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
title The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
title_full The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
title_fullStr The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
title_full_unstemmed The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
title_short The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
title_sort slc25 mitochondrial carrier family: structure and mechanism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611774/
https://www.ncbi.nlm.nih.gov/pubmed/31787485
http://dx.doi.org/10.1016/j.tibs.2019.11.001
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