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Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen

Pro-senescence therapies are increasingly being considered for the treatment of cancer. Identifying additional targets to induce senescence in cancer cells could further enable such therapies. However, screening for targets whose suppression induces senescence on a genome-wide scale is challenging,...

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Detalles Bibliográficos
Autores principales:	Schepers, Arnout, Jochems, Fleur, Lieftink, Cor, Wang, Liqin, Pogacar, Ziva, Leite de Oliveira, Rodrigo, De Conti, Giulia, Beijersbergen, Roderick L., Bernards, Rene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Cancer Genes and Networks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611779/ https://www.ncbi.nlm.nih.gov/pubmed/34158393 http://dx.doi.org/10.1158/1541-7786.MCR-21-0146

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