Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Macrophages rely on tightly integrated metabolic rewiring to clear dying neighboring cells by efferocytosis during homeostasis and disease. Here, we reveal that glutaminase (GLS) 1-mediated glutaminolysis is critical to promote apoptotic cell clearance by macrophages during homeostasis in mice. In a...

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Detalles Bibliográficos
Autores principales: Merlin, Johanna, Ivanov, Stoyan, Dumont, Adélie, Sergushichev, Alexey, Gall, Julie, Stunault, Marion, Ayrault, Marion, Vaillant, Nathalie, Castiglione, Alexia, Swain, Amanda, Orange, Francois, Gallerand, Alexandre, Berton, Thierry, Martin, Jean-Charles, Carobbio, Stefania, Masson, Justine, Gaisler-Salomon, Inna, Maechler, Pierre, Rayport, Stephen, Sluimer, Judith C., Biessen, Erik A. L., Guinamard, Rodolphe R., Gautier, Emmanuel L., Thorp, Edward B., Artyomov, Maxim N., Yvan-Charvet, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611882/
https://www.ncbi.nlm.nih.gov/pubmed/34650273
http://dx.doi.org/10.1038/s42255-021-00471-y

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