A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition of its kinase activity has thus far failed to improve patient outcomes. Here we report the small...

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Detalles Bibliográficos
Autores principales: Temps, Carolin, Lietha, Daniel, Webb, Emily R., Li, Xue-Feng, Dawson, John C., Muir, Morwenna, Macleod, Kenneth G., Valero, Teresa, Munro, Alison F., Contreras-Montoya, Rafael, Luque-Ortega, Juan R., Fraser, Craig, Beetham, Henry, Schoenherr, Christina, Lopalco, Maria, Arends, Mark J., Frame, Margaret C., Qian, Bin-Zhi, Brunton, Valerie G., Carragher, Neil O., Unciti-Broceta, Asier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611940/
https://www.ncbi.nlm.nih.gov/pubmed/34417202
http://dx.doi.org/10.1158/0008-5472.CAN-21-0613

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