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Bottom-up fabrication of a proteasome-nanopore that unravels and processes single proteins
The precise assembly and engineering of molecular machines capable of handling biomolecules play crucial roles in most single-molecule methods. In this work, using components from all three domains of life, we fabricate an integrated multi-protein complex that controls the unfolding and threading of...
Autores principales: | Zhang, Shengli, Huang, Gang, Versloot, Roderick, Bruininks, Bart Marlon Herwig, Telles de Souza, Paulo Cesar, Marrink, Siewert-Jan, Maglia, Giovanni |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612055/ https://www.ncbi.nlm.nih.gov/pubmed/34795436 http://dx.doi.org/10.1038/s41557-021-00824-w |
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