A microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids

Experimental in vitro models that capture pathophysiological characteristics of human tumours are essential for basic and translational cancer biology. Here, we describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture....

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Detalles Bibliográficos
Autores principales: Below, Christopher R., Kelly, Joanna, Brown, Alexander, Humphries, Jonathan D., Hutton, Colin, Xu, Jingshu, Lee, Brian Y., Cintas, Celia, Zhang, Xiaohong, Hernandez-Gordillo, Victor, Stockdale, Linda, Goldsworthy, Matthew A., Geraghty, Joe, Foster, Lucy, O’Reilly, Derek A., Schedding, Barbara, Askari, Janet, Burns, Jessica, Hodson, Nigel, Smith, Duncan L., Lally, Catherine, Ashton, Garry, Knight, David, Mironov, Aleksandr, Banyard, Antonia, Eble, Johannes A., Morton, Jennifer P., Humphries, Martin J., Griffith, Linda G., Jørgensen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612137/
https://www.ncbi.nlm.nih.gov/pubmed/34518665
http://dx.doi.org/10.1038/s41563-021-01085-1

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