Autocrine Vitamin D-signaling switches off pro-inflammatory programs of Th1 cells

The molecular mechanisms governing orderly shutdown and retraction of CD4(+) T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor (VDR) and the VitD-activating enzyme C...

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Detalles Bibliográficos
Autores principales: Chauss, Daniel, Freiwald, Tilo, McGregor, Reuben, Yan, Bingyu, Wang, Luopin, Nova-Lamperti, Estefania, Kumar, Dhaneshwar, Zhang, Zonghao, Teague, Heather, West, Erin E, Vannella, Kevin M, Ramos-Benitez, Marcos J, Bibby, Jack, Kelly, Audrey, Malik, Amna, Freeman, Alexandra F, Schwartz, Daniella M, Portilla, Didier, Chertow, Daniel S, John, Susan, Lavender, Paul, Kemper, Claudia, Lombardi, Giovanna, Mehta, Nehal N, Cooper, Nichola, Lionakis, Michail S, Laurence, Arian, Kazemian, Majid, Afzali, Behdad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612139/
https://www.ncbi.nlm.nih.gov/pubmed/34764490
http://dx.doi.org/10.1038/s41590-021-01080-3

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