Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer

Cytotoxic T cell (CTL) infiltration of the tumor carries the potential to limit cancer progression, but their exclusion by the immunosuppressive tumor microenvironment hampers the efficiency of immunotherapy. Here, we show that expression of the axon guidance molecule Plexin-A4 (Plxna4) in CTLs, esp...

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Detalles Bibliográficos
Autores principales: Celus, Ward, Oliveira, Ana I., Rivis, Silvia, Van Acker, Heleen H., Landeloos, Ewout, Serneels, Jens, Cafarello, Sarah Trusso, Van Herck, Yannick, Mastrantonio, Roberta, Köhler, Arnaud, Garg, Abhishek D., Flamand, Véronique, Tamagnone, Luca, Marine, Jean-Christophe, Matteo, Mario Di, Costa, Bruno M., Bechter, Oliver, Mazzone, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612191/
https://www.ncbi.nlm.nih.gov/pubmed/34815265
http://dx.doi.org/10.1158/2326-6066.CIR-21-0061

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