Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

Somatic mutations in ACVR1 are found in a quarter of children with diffuse intrinsic pontine glioma (DIPG), but there are no ACVR1 inhibitors licensed for the disease. Using an artificial intelligence–based platform to search for approved compounds for ACVR1-mutant DIPG, the combination of vandetani...

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Detalles Bibliográficos
Autores principales: Carvalho, Diana M., Richardson, Peter J., Olaciregui, Nagore, Stankunaite, Reda, Lavarino, Cinzia, Molinari, Valeria, Corley, Elizabeth A., Smith, Daniel P., Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I., Temelso, Sara, Mackay, Alan, Overington, John P., Phelan, Anne, Sheppard, David, Mackinnon, Andrew, Zebian, Bassel, Al-Sarraj, Safa, Merve, Ashirwad, Pryce, Jeremy, Grill, Jacques, Hubank, Michael, Cruz, Ofelia, Morales La Madrid, Andres, Mueller, Sabine, Carcaboso, Angel M., Carceller, Fernando, Jones, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612365/
https://www.ncbi.nlm.nih.gov/pubmed/34551970
http://dx.doi.org/10.1158/2159-8290.CD-20-1201

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