Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy

Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank from 31 genetically distinct lines, covering a representative range of tumor subtypes, and demonstrate that these reflect th...

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Detalles Bibliográficos
Autores principales: Hirt, Christian K., Booij, Tijmen H., Grob, Linda, Simmler, Patrik, Toussaint, Nora C., Keller, David, Taube, Doreen, Ludwig, Vanessa, Goryachkin, Alexander, Pauli, Chantal, Lenggenhager, Daniela, Stekhoven, Daniel J., Stirnimann, Christian U., Endhardt, Katharina, Ringnalda, Femke, Villiger, Lukas, Siebenhüner, Alexander, Karkampouna, Sofia, De Menna, Marta, Beshay, Janette, Klett, Hagen, Kruithof-de Julio, Marianna, Schüler, Julia, Schwank, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612395/
https://www.ncbi.nlm.nih.gov/pubmed/35187519
http://dx.doi.org/10.1016/j.xgen.2022.100095

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