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Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA
CRISPR-Cas systems store fragments of foreign DNA called spacers as immunological recordings used to combat future infections. Of the many spacers stored in a CRISPR array, the newest spacers are known to be prioritized for immune defense. However, the underlying mechanism remains unclear. Here we s...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612570/ https://www.ncbi.nlm.nih.gov/pubmed/35314780 http://dx.doi.org/10.1038/s41564-022-01074-3 |