HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models

Prostate cancer remains a major cause of male mortality. Genetic alteration of the PI3K/AKT/mTOR pathway is one of the key events in tumor development and progression in prostate cancer, with inactivation of the PTEN tumor suppressor being very common in this cancer type. Extensive evaluation has be...

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Detalles Bibliográficos
Autores principales: Gómez, Valentí, Galazi, Myria, Weitsman, Gregory, Monypenny, James, Al-Salemee, Fahad, Barber, Paul R., Ng, Kenrick, Beatson, Richard, Szokol, Bálint, Orfi, László, Mullen, Greg, Vanhaesebroeck, Bart, Chowdhury, Simon, Leung, Hing Y., Ng, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Targeting Drug Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612588/
https://www.ncbi.nlm.nih.gov/pubmed/35086953
http://dx.doi.org/10.1158/1535-7163.MCT-21-0320

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