Cargando…

Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones

The effect of physical activity on breast cancer risk may be partly mediated by sex steroid hormones. This review synthesized and appraised the evidence for an effect of physical activity on sex steroid hormones. Systematic searches were performed using MEDLINE (Ovid), EMBASE (Ovid), and SPORTDiscus...

Descripción completa

Detalles Bibliográficos
Autores principales: Swain, Christopher T.V., Drummond, Ann E., Boing, Leonessa, Milne, Roger L., English, Dallas R., Brown, Kristy A., van Roekel, Eline H., Dixon-Suen, Suzanne C., Lynch, Michael J., Moore, Melissa M., Gaunt, Tom R., Martin, Richard M., Lewis, Sarah J., Lynch, Brigid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612605/
https://www.ncbi.nlm.nih.gov/pubmed/34670800
http://dx.doi.org/10.1158/1055-9965.EPI-21-0437
_version_ 1783605387958681600
author Swain, Christopher T.V.
Drummond, Ann E.
Boing, Leonessa
Milne, Roger L.
English, Dallas R.
Brown, Kristy A.
van Roekel, Eline H.
Dixon-Suen, Suzanne C.
Lynch, Michael J.
Moore, Melissa M.
Gaunt, Tom R.
Martin, Richard M.
Lewis, Sarah J.
Lynch, Brigid M.
author_facet Swain, Christopher T.V.
Drummond, Ann E.
Boing, Leonessa
Milne, Roger L.
English, Dallas R.
Brown, Kristy A.
van Roekel, Eline H.
Dixon-Suen, Suzanne C.
Lynch, Michael J.
Moore, Melissa M.
Gaunt, Tom R.
Martin, Richard M.
Lewis, Sarah J.
Lynch, Brigid M.
author_sort Swain, Christopher T.V.
collection PubMed
description The effect of physical activity on breast cancer risk may be partly mediated by sex steroid hormones. This review synthesized and appraised the evidence for an effect of physical activity on sex steroid hormones. Systematic searches were performed using MEDLINE (Ovid), EMBASE (Ovid), and SPORTDiscus to identify experimental studies and prospective cohort studies that examined physical activity and estrogens, progestins, and/or androgens, as well as sex hormone binding globulin (SHBG) and glucocorticoids in pre- and postmenopausal women. Meta-analyses were performed to generate effect estimates. Risk of bias was assessed, and the GRADE system was used to appraise quality of the evidence. Twenty-eight randomized controlled trials (RCT), 81 nonrandomized interventions, and six observational studies were included. Estrogens, progesterone, and androgens mostly decreased, and SHBG increased, in response to physical activity. Effect sizes were small, and evidence quality was graded moderate or high for each outcome. Reductions in select sex steroid hormones following exercise supports the biological plausibility of the first part of the physical activity–sex hormone–breast cancer pathway. The confirmed effect of physical activity on decreasing circulating sex steroid hormones supports its causal role in preventing breast cancer. See related reviews by Lynch et al., p. 11 and Drummond et al., p. 28
format Online
Article
Text
id pubmed-7612605
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Association for Cancer Research
record_format MEDLINE/PubMed
spelling pubmed-76126052022-04-11 Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones Swain, Christopher T.V. Drummond, Ann E. Boing, Leonessa Milne, Roger L. English, Dallas R. Brown, Kristy A. van Roekel, Eline H. Dixon-Suen, Suzanne C. Lynch, Michael J. Moore, Melissa M. Gaunt, Tom R. Martin, Richard M. Lewis, Sarah J. Lynch, Brigid M. Cancer Epidemiol Biomarkers Prev Reviews The effect of physical activity on breast cancer risk may be partly mediated by sex steroid hormones. This review synthesized and appraised the evidence for an effect of physical activity on sex steroid hormones. Systematic searches were performed using MEDLINE (Ovid), EMBASE (Ovid), and SPORTDiscus to identify experimental studies and prospective cohort studies that examined physical activity and estrogens, progestins, and/or androgens, as well as sex hormone binding globulin (SHBG) and glucocorticoids in pre- and postmenopausal women. Meta-analyses were performed to generate effect estimates. Risk of bias was assessed, and the GRADE system was used to appraise quality of the evidence. Twenty-eight randomized controlled trials (RCT), 81 nonrandomized interventions, and six observational studies were included. Estrogens, progesterone, and androgens mostly decreased, and SHBG increased, in response to physical activity. Effect sizes were small, and evidence quality was graded moderate or high for each outcome. Reductions in select sex steroid hormones following exercise supports the biological plausibility of the first part of the physical activity–sex hormone–breast cancer pathway. The confirmed effect of physical activity on decreasing circulating sex steroid hormones supports its causal role in preventing breast cancer. See related reviews by Lynch et al., p. 11 and Drummond et al., p. 28 American Association for Cancer Research 2022-01-01 2021-10-20 /pmc/articles/PMC7612605/ /pubmed/34670800 http://dx.doi.org/10.1158/1055-9965.EPI-21-0437 Text en ©2021 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle Reviews
Swain, Christopher T.V.
Drummond, Ann E.
Boing, Leonessa
Milne, Roger L.
English, Dallas R.
Brown, Kristy A.
van Roekel, Eline H.
Dixon-Suen, Suzanne C.
Lynch, Michael J.
Moore, Melissa M.
Gaunt, Tom R.
Martin, Richard M.
Lewis, Sarah J.
Lynch, Brigid M.
Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
title Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
title_full Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
title_fullStr Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
title_full_unstemmed Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
title_short Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
title_sort linking physical activity to breast cancer via sex hormones, part 1: the effect of physical activity on sex steroid hormones
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612605/
https://www.ncbi.nlm.nih.gov/pubmed/34670800
http://dx.doi.org/10.1158/1055-9965.EPI-21-0437
work_keys_str_mv AT swainchristophertv linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT drummondanne linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT boingleonessa linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT milnerogerl linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT englishdallasr linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT brownkristya linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT vanroekelelineh linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT dixonsuensuzannec linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT lynchmichaelj linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT mooremelissam linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT gaunttomr linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT martinrichardm linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT lewissarahj linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones
AT lynchbrigidm linkingphysicalactivitytobreastcancerviasexhormonespart1theeffectofphysicalactivityonsexsteroidhormones