Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials

Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moeity of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against...

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Autores principales: White, Nicholas J, Watson, James A, Baird, J Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612727/
https://www.ncbi.nlm.nih.gov/pubmed/34997616
http://dx.doi.org/10.1111/bcp.15219
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author White, Nicholas J
Watson, James A
Baird, J Kevin
author_facet White, Nicholas J
Watson, James A
Baird, J Kevin
author_sort White, Nicholas J
collection PubMed
description Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moeity of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and P. ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.
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spelling pubmed-76127272022-06-01 Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials White, Nicholas J Watson, James A Baird, J Kevin Br J Clin Pharmacol Article Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moeity of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and P. ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization. 2022-06-01 2022-01-27 /pmc/articles/PMC7612727/ /pubmed/34997616 http://dx.doi.org/10.1111/bcp.15219 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
White, Nicholas J
Watson, James A
Baird, J Kevin
Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
title Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
title_full Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
title_fullStr Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
title_full_unstemmed Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
title_short Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
title_sort methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612727/
https://www.ncbi.nlm.nih.gov/pubmed/34997616
http://dx.doi.org/10.1111/bcp.15219
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