A prenylated dsRNA sensor protects against severe COVID-19

Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses releva...

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Detalles Bibliográficos
Autores principales: Wickenhagen, Arthur, Sugrue, Elena, Lytras, Spyros, Kuchi, Srikeerthana, Noerenberg, Marko, Turnbull, Matthew L., Loney, Colin, Herder, Vanessa, Allan, Jay, Jarmson, Innes, Cameron-Ruiz, Natalia, Varjak, Margus, Pinto, Rute M., Lee, Jeffrey Y., Iselin, Louisa, Palmalux, Natasha, Stewart, Douglas G., Swingler, Simon, Greenwood, Edward J. D., Crozier, Thomas W. M., Gu, Quan, Davies, Emma L., Clohisey, Sara, Wang, Bo, Trindade Maranhão Costa, Fabio, Freire Santana, Monique, de Lima Ferreira, Luiz Carlos, Murphy, Lee, Fawkes, Angie, Meynert, Alison, Grimes, Graeme, Da Silva Filho, Joao Luiz, Marti, Matthias, Hughes, Joseph, Stanton, Richard J., Wang, Eddie C. Y., Ho, Antonia, Davis, Ilan, Jarrett, Ruth F., Castello, Alfredo, Robertson, David L., Semple, Malcolm G., Openshaw, Peter J. M., Palmarini, Massimo, Lehner, Paul J., Baillie, J. Kenneth, Rihn, Suzannah J., Wilson, Sam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612834/
https://www.ncbi.nlm.nih.gov/pubmed/34581622
http://dx.doi.org/10.1126/science.abj3624

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