Cargando…
An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years
INTRODUCTION: Diffusion MRI allows non-invasive assessment of white matter connectivity in typical development and of changes due to brain injury or pathology. Probabilistic white matter atlases allow diffusion metrics to be measured in specific white matter pathways, and are a critical component in...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612846/ https://www.ncbi.nlm.nih.gov/pubmed/34210166 http://dx.doi.org/10.1089/brain.2021.0058 |
_version_ | 1783605417037791232 |
---|---|
author | Spencer, Arthur P.C. Byrne, Hollie Lee-Kelland, Richard Jary, Sally Thoresen, Marianne Cowan, Frances M. Chakkarapani, Ela Brooks, Jonathan C.W. |
author_facet | Spencer, Arthur P.C. Byrne, Hollie Lee-Kelland, Richard Jary, Sally Thoresen, Marianne Cowan, Frances M. Chakkarapani, Ela Brooks, Jonathan C.W. |
author_sort | Spencer, Arthur P.C. |
collection | PubMed |
description | INTRODUCTION: Diffusion MRI allows non-invasive assessment of white matter connectivity in typical development and of changes due to brain injury or pathology. Probabilistic white matter atlases allow diffusion metrics to be measured in specific white matter pathways, and are a critical component in spatial normalisation for group analysis. However, given the known developmental changes in white matter it may be sub-optimal to use an adult template when assessing data acquired from children. METHODS: By averaging subject-specific fibre bundles from 28 children aged from 6 to 8 years, we created an age-specific probabilistic white matter atlas for 12 major white matter tracts. Using both the newly developed and Johns Hopkins adult atlases, we compared the atlas to subject-specific fibre bundles in two independent validation cohorts, assessing accuracy in terms of volumetric overlap and measured diffusion metrics. RESULTS: Our age-specific atlas gave better overall performance than the adult atlas, achieving higher volumetric overlap with subject-specific fibre tracking and higher correlation of FA measurements with those measured from subject-specific fibre bundles. Specifically, estimates of FA values for cortico-spinal tract, uncinate fasciculus, forceps minor, cingulate gyrus part of the cingulum and anterior thalamic radiation were all significantly more accurate when estimated with an age-specific atlas. DISCUSSION: The age-specific atlas allows delineation of white matter tracts in children aged 6-8 years, without the need for tractography, more accurately than when normalising to an adult atlas. To our knowledge, this is the first publicly available probabilistic atlas of white matter tracts for this age group. |
format | Online Article Text |
id | pubmed-7612846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-76128462022-06-11 An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years Spencer, Arthur P.C. Byrne, Hollie Lee-Kelland, Richard Jary, Sally Thoresen, Marianne Cowan, Frances M. Chakkarapani, Ela Brooks, Jonathan C.W. Brain Connect Article INTRODUCTION: Diffusion MRI allows non-invasive assessment of white matter connectivity in typical development and of changes due to brain injury or pathology. Probabilistic white matter atlases allow diffusion metrics to be measured in specific white matter pathways, and are a critical component in spatial normalisation for group analysis. However, given the known developmental changes in white matter it may be sub-optimal to use an adult template when assessing data acquired from children. METHODS: By averaging subject-specific fibre bundles from 28 children aged from 6 to 8 years, we created an age-specific probabilistic white matter atlas for 12 major white matter tracts. Using both the newly developed and Johns Hopkins adult atlases, we compared the atlas to subject-specific fibre bundles in two independent validation cohorts, assessing accuracy in terms of volumetric overlap and measured diffusion metrics. RESULTS: Our age-specific atlas gave better overall performance than the adult atlas, achieving higher volumetric overlap with subject-specific fibre tracking and higher correlation of FA measurements with those measured from subject-specific fibre bundles. Specifically, estimates of FA values for cortico-spinal tract, uncinate fasciculus, forceps minor, cingulate gyrus part of the cingulum and anterior thalamic radiation were all significantly more accurate when estimated with an age-specific atlas. DISCUSSION: The age-specific atlas allows delineation of white matter tracts in children aged 6-8 years, without the need for tractography, more accurately than when normalising to an adult atlas. To our knowledge, this is the first publicly available probabilistic atlas of white matter tracts for this age group. 2022-06-01 2021-08-23 /pmc/articles/PMC7612846/ /pubmed/34210166 http://dx.doi.org/10.1089/brain.2021.0058 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. |
spellingShingle | Article Spencer, Arthur P.C. Byrne, Hollie Lee-Kelland, Richard Jary, Sally Thoresen, Marianne Cowan, Frances M. Chakkarapani, Ela Brooks, Jonathan C.W. An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years |
title | An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years |
title_full | An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years |
title_fullStr | An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years |
title_full_unstemmed | An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years |
title_short | An Age-Specific Atlas for Delineation of White Matter Pathways in Children Aged 6-8 Years |
title_sort | age-specific atlas for delineation of white matter pathways in children aged 6-8 years |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612846/ https://www.ncbi.nlm.nih.gov/pubmed/34210166 http://dx.doi.org/10.1089/brain.2021.0058 |
work_keys_str_mv | AT spencerarthurpc anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT byrnehollie anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT leekellandrichard anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT jarysally anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT thoresenmarianne anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT cowanfrancesm anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT chakkarapaniela anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT brooksjonathancw anagespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT spencerarthurpc agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT byrnehollie agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT leekellandrichard agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT jarysally agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT thoresenmarianne agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT cowanfrancesm agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT chakkarapaniela agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years AT brooksjonathancw agespecificatlasfordelineationofwhitematterpathwaysinchildrenaged68years |