Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV

We investigated the contributions of thymidine analogue (TA) and tenofovir disoproxil fumarate (TDF) anti-retroviral therapy on renal mitochondrial toxicity in Ghanaian PWH. Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had se...

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Autores principales: Hunt, Matthew, Phillips, Richard, Hardy, Yasmine, Owusu, Dorcas O, Mitchelmore, Rosa, Durrani, Mehrab, Payne, Brendan AI, Chadwick, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612849/
https://www.ncbi.nlm.nih.gov/pubmed/35652677
http://dx.doi.org/10.1097/QAD.0000000000003209
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author Hunt, Matthew
Phillips, Richard
Hardy, Yasmine
Owusu, Dorcas O
Mitchelmore, Rosa
Durrani, Mehrab
Payne, Brendan AI
Chadwick, David R
author_facet Hunt, Matthew
Phillips, Richard
Hardy, Yasmine
Owusu, Dorcas O
Mitchelmore, Rosa
Durrani, Mehrab
Payne, Brendan AI
Chadwick, David R
author_sort Hunt, Matthew
collection PubMed
description We investigated the contributions of thymidine analogue (TA) and tenofovir disoproxil fumarate (TDF) anti-retroviral therapy on renal mitochondrial toxicity in Ghanaian PWH. Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had sequenced from TA to TDF. However, mild renal impairment was associated with mitochondrial DNA damage in TDF but not TA-treated PWH. These data support the continued use of TDF in resource limited settings.
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spelling pubmed-76128492022-06-13 Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV Hunt, Matthew Phillips, Richard Hardy, Yasmine Owusu, Dorcas O Mitchelmore, Rosa Durrani, Mehrab Payne, Brendan AI Chadwick, David R AIDS Article We investigated the contributions of thymidine analogue (TA) and tenofovir disoproxil fumarate (TDF) anti-retroviral therapy on renal mitochondrial toxicity in Ghanaian PWH. Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had sequenced from TA to TDF. However, mild renal impairment was associated with mitochondrial DNA damage in TDF but not TA-treated PWH. These data support the continued use of TDF in resource limited settings. 2022-06-01 2022-03-04 /pmc/articles/PMC7612849/ /pubmed/35652677 http://dx.doi.org/10.1097/QAD.0000000000003209 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Hunt, Matthew
Phillips, Richard
Hardy, Yasmine
Owusu, Dorcas O
Mitchelmore, Rosa
Durrani, Mehrab
Payne, Brendan AI
Chadwick, David R
Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV
title Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV
title_full Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV
title_fullStr Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV
title_full_unstemmed Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV
title_short Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people living with HIV
title_sort renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in african people living with hiv
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612849/
https://www.ncbi.nlm.nih.gov/pubmed/35652677
http://dx.doi.org/10.1097/QAD.0000000000003209
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