Community guidelines for GPCR ligand bias: IUPHAR review 32

GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm requires that we now characterize physiological signal...

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Detalles Bibliográficos
Autores principales: Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612872/
https://www.ncbi.nlm.nih.gov/pubmed/35106752
http://dx.doi.org/10.1111/bph.15811

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