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4-Octyl-itaconate and dimethyl fumarate inhibit COX2 expression and prostaglandin production in macrophages

Prostaglandins (PGs) are important proinflammatory lipid mediators, the significance of which is highlighted by the widespread and efficacious use of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of inflammation. 4-Octyl itaconate (4-OI), a derivative of the Krebs cycle-derived met...

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Detalles Bibliográficos
Autores principales:	Diskin, Ciana, Zotta, Alessia, Corcoran, Sarah E., Tyrrell, Victoria J., Zaslona, Zbigniew, O’Donnell, Valerie B., O’Neill, Luke A.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613254/ https://www.ncbi.nlm.nih.gov/pubmed/34635585 http://dx.doi.org/10.4049/jimmunol.2100488

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