Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control

Background: MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to the activating receptor NKG2D on cytotoxic lymphocytes. MICA and MICB are highly polymorphic molecules with prevalent expression on several types of solid tumors and limited expressio...

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Detalles Bibliográficos
Autores principales: Bléry, Mathieu, Mrabet-Kraiem, Manel, Morel, Ariane, Lhospice, Florence, Bregeon, Delphine, Bonnafous, Cécile, Gauthier, Laurent, Rossi, Benjamin, Remark, Romain, Cornen, Stéphanie, Anceriz, Nadia, Viaud, Nicolas, Trichard, Sylvia, Carpentier, Sabrina, Joulin-Giet, Alix, Grondin, Gwendoline, Liptakova, Veronika, Kim, Younghoon, Daniel, Laurent, Haffner, Aurélie, Macagno, Nicolas, Pouyet, Laurent, Perrot, Ivan, Paturel, Carine, Morel, Yannis, Steinle, Alexander, Romagné, François, Narni-Mancinelli, Emilie, Vivier, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613279/
https://www.ncbi.nlm.nih.gov/pubmed/35967081
http://dx.doi.org/10.12688/openreseurope.13314.2

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