In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

Transplantation of B cells engineered ex vivo to secrete broadly neutralizing antibodies (bNAbs) has shown efficacy in disease models. However, clinical translation of this approach would require specialized medical centers, technically demanding protocols and MHC compatibility of donor cells and re...

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Detalles Bibliográficos
Autores principales: Nahmad, A. D., Lazzarotto, C. R., Zelikson, N., Kustin, T., Tenuta, M., Huang, D., Reuveni, I., Nataf, D., Raviv, Y., Horovitz-Fried, M., Dotan, I., Carmi, Y., Rosin-Arbesfeld, R., Nemazee, D., Voss, J.E., Stern, A., Tsai, S. Q., Barzel, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613293/
https://www.ncbi.nlm.nih.gov/pubmed/35681059
http://dx.doi.org/10.1038/s41587-022-01328-9

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