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Water contact angle is not a good predictor of biological responses to materials

Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this article, the authors present a perspective emerging f...

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Detalles Bibliográficos
Autores principales: Alexander, Morgan R., Williams, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613460/
https://www.ncbi.nlm.nih.gov/pubmed/28683556
http://dx.doi.org/10.1116/1.4989843
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author Alexander, Morgan R.
Williams, Paul
author_facet Alexander, Morgan R.
Williams, Paul
author_sort Alexander, Morgan R.
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description Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this article, the authors present a perspective emerging from their work that has failed to find relationships between WCA and microbial and stem cell attachment within large diversity material libraries and compare with the literature concluding that such simple rules are (unfortunately) wholly inadequate to explain cell–material interactions.
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spelling pubmed-76134602022-08-29 Water contact angle is not a good predictor of biological responses to materials Alexander, Morgan R. Williams, Paul Biointerphases Article Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this article, the authors present a perspective emerging from their work that has failed to find relationships between WCA and microbial and stem cell attachment within large diversity material libraries and compare with the literature concluding that such simple rules are (unfortunately) wholly inadequate to explain cell–material interactions. 2017-07-06 2017-07-06 /pmc/articles/PMC7613460/ /pubmed/28683556 http://dx.doi.org/10.1116/1.4989843 Text en https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Alexander, Morgan R.
Williams, Paul
Water contact angle is not a good predictor of biological responses to materials
title Water contact angle is not a good predictor of biological responses to materials
title_full Water contact angle is not a good predictor of biological responses to materials
title_fullStr Water contact angle is not a good predictor of biological responses to materials
title_full_unstemmed Water contact angle is not a good predictor of biological responses to materials
title_short Water contact angle is not a good predictor of biological responses to materials
title_sort water contact angle is not a good predictor of biological responses to materials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613460/
https://www.ncbi.nlm.nih.gov/pubmed/28683556
http://dx.doi.org/10.1116/1.4989843
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