Cargando…

Behaviorally relevant decision coding in primary somatosensory cortex neurons

Primary sensory cortex is thought to process incoming sensory information, while decision variables important for driving behavior are assumed to arise downstream in the processing hierarchy. We used population two-photon calcium imaging and targeted two-photon optogenetic stimulation of neurons in...

Descripción completa

Detalles Bibliográficos
Autores principales: Buetfering, Christina, Zhang, Zihui, Pitsiani, Margarita, Smallridge, John, Boven, Ellen, McElligott, Sacha, Häusser, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613627/
https://www.ncbi.nlm.nih.gov/pubmed/36042310
http://dx.doi.org/10.1038/s41593-022-01151-0
_version_ 1783605501710303232
author Buetfering, Christina
Zhang, Zihui
Pitsiani, Margarita
Smallridge, John
Boven, Ellen
McElligott, Sacha
Häusser, Michael
author_facet Buetfering, Christina
Zhang, Zihui
Pitsiani, Margarita
Smallridge, John
Boven, Ellen
McElligott, Sacha
Häusser, Michael
author_sort Buetfering, Christina
collection PubMed
description Primary sensory cortex is thought to process incoming sensory information, while decision variables important for driving behavior are assumed to arise downstream in the processing hierarchy. We used population two-photon calcium imaging and targeted two-photon optogenetic stimulation of neurons in layer 2/3 of mouse primary somatosensory cortex (S1) during a texture discrimination task to test for the presence of decision signals and probe their behavioral relevance. Small but distinct populations of neurons carried information about the stimulus irrespective of the behavioral outcome (‘stimulus neurons’), or about the choice irrespective of the presented stimulus (‘decision neurons’). Decision neurons show categorical coding that develops during learning, and lack a conclusive decision signal in miss trials. All-optical photostimulation of decision neurons improves behavioral performance, establishing a causal role in driving behavior. The fact that stimulus and decision neurons are intermingled challenges the idea of S1 as a purely sensory area, and causal perturbation suggests a direct involvement of S1 decision neurons in the decision-making process.
format Online
Article
Text
id pubmed-7613627
institution National Center for Biotechnology Information
language English
publishDate 2022
record_format MEDLINE/PubMed
spelling pubmed-76136272022-09-23 Behaviorally relevant decision coding in primary somatosensory cortex neurons Buetfering, Christina Zhang, Zihui Pitsiani, Margarita Smallridge, John Boven, Ellen McElligott, Sacha Häusser, Michael Nat Neurosci Article Primary sensory cortex is thought to process incoming sensory information, while decision variables important for driving behavior are assumed to arise downstream in the processing hierarchy. We used population two-photon calcium imaging and targeted two-photon optogenetic stimulation of neurons in layer 2/3 of mouse primary somatosensory cortex (S1) during a texture discrimination task to test for the presence of decision signals and probe their behavioral relevance. Small but distinct populations of neurons carried information about the stimulus irrespective of the behavioral outcome (‘stimulus neurons’), or about the choice irrespective of the presented stimulus (‘decision neurons’). Decision neurons show categorical coding that develops during learning, and lack a conclusive decision signal in miss trials. All-optical photostimulation of decision neurons improves behavioral performance, establishing a causal role in driving behavior. The fact that stimulus and decision neurons are intermingled challenges the idea of S1 as a purely sensory area, and causal perturbation suggests a direct involvement of S1 decision neurons in the decision-making process. 2022-09 2022-08-30 /pmc/articles/PMC7613627/ /pubmed/36042310 http://dx.doi.org/10.1038/s41593-022-01151-0 Text en https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Buetfering, Christina
Zhang, Zihui
Pitsiani, Margarita
Smallridge, John
Boven, Ellen
McElligott, Sacha
Häusser, Michael
Behaviorally relevant decision coding in primary somatosensory cortex neurons
title Behaviorally relevant decision coding in primary somatosensory cortex neurons
title_full Behaviorally relevant decision coding in primary somatosensory cortex neurons
title_fullStr Behaviorally relevant decision coding in primary somatosensory cortex neurons
title_full_unstemmed Behaviorally relevant decision coding in primary somatosensory cortex neurons
title_short Behaviorally relevant decision coding in primary somatosensory cortex neurons
title_sort behaviorally relevant decision coding in primary somatosensory cortex neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613627/
https://www.ncbi.nlm.nih.gov/pubmed/36042310
http://dx.doi.org/10.1038/s41593-022-01151-0
work_keys_str_mv AT buetferingchristina behaviorallyrelevantdecisioncodinginprimarysomatosensorycortexneurons
AT zhangzihui behaviorallyrelevantdecisioncodinginprimarysomatosensorycortexneurons
AT pitsianimargarita behaviorallyrelevantdecisioncodinginprimarysomatosensorycortexneurons
AT smallridgejohn behaviorallyrelevantdecisioncodinginprimarysomatosensorycortexneurons
AT bovenellen behaviorallyrelevantdecisioncodinginprimarysomatosensorycortexneurons
AT mcelligottsacha behaviorallyrelevantdecisioncodinginprimarysomatosensorycortexneurons
AT haussermichael behaviorallyrelevantdecisioncodinginprimarysomatosensorycortexneurons