HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene translocations. In addition to its demethylase activity, LSD1 has a critical scaffolding function at genomic sites occupied by the SNAG domain...

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Detalles Bibliográficos
Autores principales: Maiques-Diaz, Alba, Nicosia, Luciano, Basma, Naseer J., Romero-Camarero, Isabel, Camera, Francesco, Spencer, Gary J., Amaral, Fabio M. R., Simeoni, Fabrizio, Wingelhofer, Bettina, Williamson, Andrew J. K., Pierce, Andrew, Whetton, Anthony D., Somervaille, Tim C. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613766/
https://www.ncbi.nlm.nih.gov/pubmed/36171271
http://dx.doi.org/10.1038/s41388-022-02471-y

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