Adult human kidney organoids originate from CD24(+) cells and represent an advanced model for adult polycystic kidney disease

Adult kidney organoids have been described as strictly tubular epithelial and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a distinct CD24(+) epithelial subpopulation. Long-term-cultured CD24(+)-derived tubuloids represent a f...

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Detalles Bibliográficos
Autores principales: Xu, Yaoxian, Kuppe, Christoph, Perales-Patón, Javier, Hayat, Sikander, Kranz, Jennifer, Abdallah, Ali T., Nagai, James, Li, Zhijian, Peisker, Fabian, Saritas, Turgay, Halder, Maurice, Menzel, Sylvia, Hoeft, Konrad, Kenter, Annegien, Kim, Hyojin, van Roeyen, Claudia R. C., Lehrke, Michael, Moellmann, Julia, Speer, Thimoteus, Buhl, Eva M., Hoogenboezem, Remco, Boor, Peter, Jansen, Jitske, Knopp, Cordula, Kurth, Ingo, Smeets, Bart, Bindels, Eric, Reinders, Marlies E. J., Baan, Carla, Gribnau, Joost, Hoorn, Ewout J., Steffens, Joachim, Huber, Tobias B, Costa, Ivan, Floege, Jürgen, Schneider, Rebekka K., Saez-Rodriguez, Julio, Freedman, Benjamin S., Kramann, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613830/
https://www.ncbi.nlm.nih.gov/pubmed/36303074
http://dx.doi.org/10.1038/s41588-022-01202-z

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