To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions

Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and...

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Detalles Bibliográficos
Autores principales: Müller, Nils Christian, Romagnani, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613863/
https://www.ncbi.nlm.nih.gov/pubmed/36372017
http://dx.doi.org/10.1016/j.smim.2022.101670
Descripción
Sumario:Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and differences between group 1 ILC subsets in both mice and humans, discuss how the tissue and tumor microenvironment shapes their phenotype and functions, as well as describe their contrasting roles in the response to different cancers.

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