To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions

Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and...

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Detalles Bibliográficos
Autores principales: Müller, Nils Christian, Romagnani, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613863/
https://www.ncbi.nlm.nih.gov/pubmed/36372017
http://dx.doi.org/10.1016/j.smim.2022.101670
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author Müller, Nils Christian
Romagnani, Chiara
author_facet Müller, Nils Christian
Romagnani, Chiara
author_sort Müller, Nils Christian
collection PubMed
description Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and differences between group 1 ILC subsets in both mice and humans, discuss how the tissue and tumor microenvironment shapes their phenotype and functions, as well as describe their contrasting roles in the response to different cancers.
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spelling pubmed-76138632022-11-29 To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions Müller, Nils Christian Romagnani, Chiara Semin Immunol Article Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and differences between group 1 ILC subsets in both mice and humans, discuss how the tissue and tumor microenvironment shapes their phenotype and functions, as well as describe their contrasting roles in the response to different cancers. Academic Press 2022-11 /pmc/articles/PMC7613863/ /pubmed/36372017 http://dx.doi.org/10.1016/j.smim.2022.101670 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Müller, Nils Christian
Romagnani, Chiara
To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions
title To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions
title_full To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions
title_fullStr To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions
title_full_unstemmed To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions
title_short To kill or not to kill – The role of the tumor microenvironment in shaping group 1 ILC functions
title_sort to kill or not to kill – the role of the tumor microenvironment in shaping group 1 ilc functions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613863/
https://www.ncbi.nlm.nih.gov/pubmed/36372017
http://dx.doi.org/10.1016/j.smim.2022.101670
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