The appearance of phagocytic microglia in the postnatal brain of Niemann Pick type C mice is developmentally regulated and underscores shortfalls in fine odor discrimination

The loss of NPC1 or NPC2 function results in cholesterol and sphingolipid dyshomeostasis that impairs developmental trajectories, predisposing the postnatal brain to the appearance of pathological signs, including progressive and stereotyped Purkinje cell loss and microgliosis. Despite increasing ev...

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Detalles Bibliográficos
Autores principales: Rava, Alessandro, La Rosa, Piergiorgio, Palladino, Giampiero, Dragotto, Jessica, Totaro, Antonio, Tiberi, Jessica, Canterini, Sonia, Oddi, Sergio, Fiorenza, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613956/
https://www.ncbi.nlm.nih.gov/pubmed/36322609
http://dx.doi.org/10.1002/jcp.30909

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