Cargando…

Nur77-Tempo mice reveal T cell steady state antigen recognition

In lymphocytes, Nr4a gene expression is specifically regulated by antigen receptor signalling, making them ideal targets for use as distal T cell receptor (TCR) reporters. Nr4a3-Timer of cell kinetics and activity (Tocky) mice are a ground-breaking tool to report TCR-driven Nr4a3 expression using Fl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elliot, Thomas A. E., Jennings, Emma K., Lecky, David A. J., Rouvray, Sophie, Mackie, Gillian M., Scarfe, Lisa, Sheriff, Lozan, Ono, Masahiro, Maslowski, Kendle M., Bending, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614040/ https://www.ncbi.nlm.nih.gov/pubmed/36704407 http://dx.doi.org/10.1093/discim/kyac009

Ejemplares similares

Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium
por: Scarfe, Lisa, et al.
Publicado: (2021)

Flow cytometric analysis of CD4+ T cell reactivation following anti-PD1 immunotherapy in a transgenic mouse model
por: Sheriff, Lozan, et al.
Publicado: (2022)

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength
por: Elliot, Thomas A.E., et al.
Publicado: (2021)

T cell biomarkers come to the fore in cancer immunotherapy
por: Sheriff, Lozan, et al.
Publicado: (2023)

Application of dual Nr4a1-GFP Nr4a3-Tocky reporter mice to study T cell receptor signaling by flow cytometry
por: Jennings, Emma K., et al.
Publicado: (2021)

Orphan Nuclear Receptor Nur77 Is Involved in Caspase-independent Macrophage Cell Death
por: Kim, Sung Ouk, et al.
Publicado: (2003)

‘Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity
por: Lith, Sanne C., et al.
Publicado: (2020)

Regulation of Nuclear Receptor Nur77 by miR-124
por: Tenga, Alexa, et al.
Publicado: (2016)

Nur77 deficiency leads to systemic inflammation in elderly mice
por: Li, Xiu-Ming, et al.
Publicado: (2015)

Characteristics of Nur77 and its ligands as potential anticancer compounds
por: Wu, Lingjuan, et al.
Publicado: (2018)

Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
por: Tel-Karthaus, Nina, et al.
Publicado: (2018)

Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
por: Hu, Mengjie, et al.
Publicado: (2018)

New Avenues for Antiinflammatory Signaling of Nur77 in Acute Lung Injury
por: Sommer, Natascha, et al.
Publicado: (2021)

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77
por: Chao, Lily C., et al.
Publicado: (2009)

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization
por: Chao, Lily C., et al.
Publicado: (2012)

Progress and Promise of Nur77-based Therapeutics for Central Nervous System Disorders
por: Liu, Lu, et al.
Publicado: (2021)

Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis
por: Zhang, Qian, et al.
Publicado: (2023)

Inhibition of β-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77
por: Sun, Zhe, et al.
Publicado: (2011)

Female Nur77-Deficient Mice Show Increased Susceptibility to Diet-Induced Obesity
por: Perez-Sieira, Sonia, et al.
Publicado: (2013)

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK
por: Liu, Jie, et al.
Publicado: (2017)

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
por: Huo, Jianxin, et al.
Publicado: (2020)

FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis
por: Kim, Hansle, et al.
Publicado: (2021)

Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish
por: Xu, Yang, et al.
Publicado: (2022)

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice
por: Cai, Xinyu, et al.
Publicado: (2023)

Hederagenin suppresses glioma cell biological activities via Nur77 in vitro study
por: Dai, Yuxiang, et al.
Publicado: (2022)

Resistance of Foxp3+ Regulatory T Cells to Nur77-Induced Apoptosis Promotes Allograft Survival
por: Tao, Ran, et al.
Publicado: (2008)

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self- reactive T cells
Publicado: (1996)

Orphan Nuclear Receptor Nur77 Regulates Androgen Receptor Gene Expression in Mouse Ovary
por: Dai, Anyi, et al.
Publicado: (2012)

Human-Gyrovirus-Apoptin Triggers Mitochondrial Death Pathway—Nur77 is Required for Apoptosis Triggering
por: Chaabane, Wiem, et al.
Publicado: (2014)

Simultaneous targeting of MyD88 and Nur77 as an effective approach for the treatment of inflammatory diseases
por: Uzma, Saqib, et al.
Publicado: (2016)

Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
por: Li, Xiu-Ming, et al.
Publicado: (2016)

The Stimulative Effect of Yangjing Capsule on Testosterone Synthesis through Nur77 Pathway in Leydig Cells
por: Gu, Yalong, et al.
Publicado: (2015)

Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling
por: Medzikovic, Lejla, et al.
Publicado: (2015)

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice
por: Cortez-Toledo, Omar, et al.
Publicado: (2017)

Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)
por: Reddy, Aravind T., et al.
Publicado: (2020)

Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes
por: Medzikovic, Lejla, et al.
Publicado: (2021)

Cytokine exposure mediates transcriptional activation of the orphan nuclear receptor Nur77 in hematopoietic cells
por: di Martino, Orsola, et al.
Publicado: (2021)

Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis
por: Yuan, Ruosen, et al.
Publicado: (2022)

Nur77 Prevents Osteoporosis by Inhibiting the NF‐κB Signalling Pathway and Osteoclast Differentiation
por: Tian, Huanlian, et al.
Publicado: (2022)

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
por: Koenis, Duco Steven, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rm21e76u7obkvn8lp8tn9fh2be