Cargando…
Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation
The compartmentation and distribution of metabolites between mitochondria and the rest of the cell is a key parameter of cell signalling and pathology. Here, we have developed a rapid fractionation procedure that enables us to take mouse heart and liver from in vivo and within ~ 30 s stabilise the d...
Autores principales: | Allen, Fay M., Costa, Ana S. H., Gruszczyk, Anja V., Bates, Georgina R., Prag, Hiran A., Nikitopoulou, Efterpi, Viscomi, Carlo, Frezza, Christian, James, Andrew M., Murphy, Michael P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614208/ https://www.ncbi.nlm.nih.gov/pubmed/36217875 http://dx.doi.org/10.1002/1873-3468.14511 |
Ejemplares similares
-
Mechanism of succinate efflux upon reperfusion of the ischaemic heart
por: Prag, Hiran A, et al.
Publicado: (2020) -
Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury
por: Gruszczyk, Anja V., et al.
Publicado: (2022) -
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation
por: Martin, Jack L., et al.
Publicado: (2019) -
DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury
por: De Lazzari, Federica, et al.
Publicado: (2021) -
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
por: Ryan, Dylan Gerard, et al.
Publicado: (2021)