Stereoselective Syntheses of Masked β-Amino Acid Containing Phthalides

We herein report a protocol for the asymmetric aldol-initiated cascade addition of isoxazolidin-5-ones to ortho-cyanobenzaldehydes by using Takemoto’s bifunctional organocatalyst. This approach allows for the synthesis of various novel β(2,2)-amino acid-phthalide conjugates with good enantio- and di...

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Detalles Bibliográficos
Autores principales: Serusi, Lorenzo, Zebrowski, Paul, Schörgenhumer, Johannes, Massa, Antonio, Waser, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614226/
https://www.ncbi.nlm.nih.gov/pubmed/36845268
http://dx.doi.org/10.1002/hlca.202200110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614226/
https://www.ncbi.nlm.nih.gov/pubmed/36845268
http://dx.doi.org/10.1002/hlca.202200110

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