The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance

Tuberculosis treatment requires months-long combination chemotherapy with multiple drugs, with shorter treatments leading to relapses. A major impediment to shortening treatment is that Mycobacterium tuberculosis becomes tolerant to the administered drugs, starting early after infection and within d...

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Detalles Bibliográficos
Autores principales: Lake, M. Alexandra, Adams, Kristin N., Nie, Feilin, Fowler, Elaine, Verma, Amit K., Dei, Silvia, Teodori, Elisabetta, Sherman, David R., Edelstein, Paul H., Spring, David R., Troll, Mark, Ramakrishnan, Lalita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614234/
https://www.ncbi.nlm.nih.gov/pubmed/36763530
http://dx.doi.org/10.1073/pnas.2215512120

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