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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Targeted protein degradation is a novel pharmacology established by drugs that recruit target proteins to E3 ubiquitin ligases. Based on the structure of the degrader and the target, different E3 interfaces are critically involved, thus forming defined “functional hotspots”. Understanding disruptive...

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Detalles Bibliográficos
Autores principales:	Hanzl, Alexander, Casement, Ryan, Imrichova, Hana, Hughes, Scott J., Barone, Eleonora, Testa, Andrea, Bauer, Sophie, Wright, Jane, Brand, Matthias, Ciulli, Alessio, Winter, Georg E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614256/ https://www.ncbi.nlm.nih.gov/pubmed/36329119 http://dx.doi.org/10.1038/s41589-022-01177-2

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