Cargando…

Identification of prolactin receptor variants with diverse effects on receptor signalling

The prolactin receptor (PRLR) signals predominantly through the JAK2-STAT5 pathway regulating multiple physiological functions relating to fertility, lactation, and metabolism. However, the molecular pathology and role of PRLR mutations and signalling are incompletely defined, with progress hampered...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gorvin, Caroline M, Newey, Paul J, Thakker, Rajesh V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614258/ https://www.ncbi.nlm.nih.gov/pubmed/36445946 http://dx.doi.org/10.1530/JME-22-0164

Ejemplares similares

Association of prolactin receptor (PRLR) variants with prolactinomas
por: Gorvin, Caroline M, et al.
Publicado: (2019)

The prolactin receptor: Diverse and emerging roles in pathophysiology
por: Gorvin, Caroline M.
Publicado: (2015)

SAT-036 Extracellular Domain Calcium-Sensing Receptor (CaSR) Mutations Leading to Hypercalcemic and Hypocalcemic Disorders Cluster at the Homodimeric Interface
por: Olesen, Mie, et al.
Publicado: (2019)

The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell lines
por: Lines, Kate E, et al.
Publicado: (2021)

OR07-06 The Roles of GNAQ and GNA11 in Calcium-Sensing Receptor (CaSR) Signalling
por: Gluck, Anna K, et al.
Publicado: (2020)

The Importance of Functionally Characterizing Calcium-Sensing Receptor Variants in Individuals With Hypercalcemia
por: Gorvin, Caroline M
Publicado: (2022)

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias
por: Gorvin, Caroline M, et al.
Publicado: (2018)

Effects of deletion of the prolactin receptor on ovarian gene expression
por: Grosdemouge, Isabelle, et al.
Publicado: (2003)

Role of Prolactin Receptors in Lymphangioleiomyomatosis
por: Alkharusi, Amira, et al.
Publicado: (2016)

The Diversity of Gut Microbiota at Weaning Is Altered in Prolactin Receptor-Null Mice
por: Luzardo-Ocampo, Ivan, et al.
Publicado: (2023)

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders
por: Babinsky, Valerie N., et al.
Publicado: (2016)

Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling
por: Rizk, Shahir S, et al.
Publicado: (2015)

Is prolactin receptor signaling a target in dopamine-resistant prolactinomas?
por: Ferraris, Jimena
Publicado: (2023)

Pituitary Androgen Receptor Signalling Regulates Prolactin but Not Gonadotrophins in the Male Mouse
por: O’Hara, Laura, et al.
Publicado: (2015)

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity
por: Gorvin, Caroline M., et al.
Publicado: (2018)

The role of Prolactin/Prolactin Receptor polymorphisms and expression in breast cancer susceptibility and outcome
por: Sa-nguanraksa, Doonyapat, et al.
Publicado: (2020)

The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level
por: Kolomiiets, Olena, et al.
Publicado: (2021)

Prolactin and Prolactin Receptor Expression in Rat, Small Intestine, Intraepithelial Lymphocytes During Neonatal Developmen
por: Urtishak, Sandra L., et al.
Publicado: (2001)

Large-scale exome datasets reveal a new class of adaptor-related protein complex 2 sigma subunit (AP2σ) mutations, located at the interface with the AP2 alpha subunit, that impair calcium-sensing receptor signalling
por: Gorvin, Caroline M, et al.
Publicado: (2018)

Prolactin enhances T regulatory cell promotion of breast cancer through the long form prolactin receptor
por: Chen, Kuan-Hui Ethan, et al.
Publicado: (2021)

Multiple cell types in the oviduct express the prolactin receptor
por: Radecki, Kelly C., et al.
Publicado: (2022)

Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues
por: Devi, Y Sangeeta, et al.
Publicado: (2009)

Prolactin receptor signaling induces acquisition of chemoresistance and reduces clonogenicity in acute myeloid leukemia
por: Cuesta-Casanovas, Laia, et al.
Publicado: (2023)

Human Cytomegalovirus Infection Induces High Expression of Prolactin and Prolactin Receptors in Ovarian Cancer
por: Rahbar, Afsar, et al.
Publicado: (2020)

Genetics of Monogenic Disorders of Calcium and Bone Metabolism
por: Newey, Paul J, et al.
Publicado: (2022)

Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2
por: Hannan, Fadil M, et al.
Publicado: (2021)

Expression of Prolactin Receptor on the Surface of Quail Spermatozoa
por: Hiyama, Gen, et al.
Publicado: (2016)

Heterogeneity of G protein activation by the calcium-sensing receptor
por: Abid, Hasnat Ali, et al.
Publicado: (2021)

Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer
por: O’Sullivan, Ciara C., et al.
Publicado: (2016)

Inhibition of the Activity of Cyclophilin A Impedes Prolactin Receptor-Mediated Signaling, Mammary Tumorigenesis, and Metastases
por: Hakim, Shawn, et al.
Publicado: (2020)

OR0304 Novel Dual Antagonists Of The Growth Hormone Receptor And The Prolactin Receptor
por: Basu, Reetobrata, et al.
Publicado: (2023)

The human intermediate prolactin receptor is a mammary proto-oncogene
por: Grible, Jacqueline M., et al.
Publicado: (2021)

Genetic approaches to metabolic bone diseases
por: Hannan, Fadil M., et al.
Publicado: (2018)

Prolactin Receptor (PRLR) Isoform Expression in the Murine Oviduct
por: Radecki, Kelly C, et al.
Publicado: (2021)

Role of EGF/ERBB1 in the transcriptional regulation of the prolactin receptor independent of estrogen and prolactin in breast cancer cells
por: Kavarthapu, Raghuveer, et al.
Publicado: (2016)

Essential role of endogenous prolactin and CDK7 in estrogen-induced upregulation of the prolactin receptor in breast cancer cells
por: Kavarthapu, Raghuveer, et al.
Publicado: (2017)

RISING STARS: Targeting G protein-coupled receptors to regulate energy homeostasis
por: Jamaluddin, Aqfan, et al.
Publicado: (2023)

SAT-130 The Intermediate Prolactin Receptor Is a Breast Cancer Oncogene
por: Grible, Jacqueline M, et al.
Publicado: (2020)

Estrogen receptor α/prolactin receptor bilateral crosstalk promotes bromocriptine resistance in prolactinomas
por: Xiao, Zhengzheng, et al.
Publicado: (2020)

Seasonal expressions of prolactin, prolactin receptor and STAT5 in the scented glands of the male muskrats (Ondatra zibethicus)
por: Xie, Wenqian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0a4elto2u6ld8077i537mrfue4