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How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment

OBJECTIVE: While brain stimulation therapies such as deep brain stimulation for Parkinson’s disease (PD) can be effective, they have yet to reach their full potential across neurological disorders. Entraining neuronal rhythms using rhythmic brain stimulation has been suggested as a new therapeutic m...

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Detalles Bibliográficos
Autores principales: Duchet, Benoit, Sermon, James J, Weerasinghe, Gihan, Denison, Timothy, Bogacz, Rafal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614323/
https://www.ncbi.nlm.nih.gov/pubmed/36880684
http://dx.doi.org/10.1088/1741-2552/acbc4a
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author Duchet, Benoit
Sermon, James J
Weerasinghe, Gihan
Denison, Timothy
Bogacz, Rafal
author_facet Duchet, Benoit
Sermon, James J
Weerasinghe, Gihan
Denison, Timothy
Bogacz, Rafal
author_sort Duchet, Benoit
collection PubMed
description OBJECTIVE: While brain stimulation therapies such as deep brain stimulation for Parkinson’s disease (PD) can be effective, they have yet to reach their full potential across neurological disorders. Entraining neuronal rhythms using rhythmic brain stimulation has been suggested as a new therapeutic mechanism to restore neurotypical behaviour in conditions such as chronic pain, depression, and Alzheimer’s disease. However, theoretical and experimental evidence indicate that brain stimulation can also entrain neuronal rhythms at sub- and super-harmonics, far from the stimulation frequency. Crucially, these counterintuitive effects could be harmful to patients, for example by triggering debilitating involuntary movements in PD. We therefore seek a principled approach to selectively promote rhythms close to the stimulation frequency, while avoiding potential harmful effects by preventing entrainment at sub- and super-harmonics. APPROACH: Our open-loop approach to selective entrainment, dithered stimulation, consists in adding white noise to the stimulation period. MAIN RESULTS: We theoretically establish the ability of dithered stimulation to selectively entrain a given brain rhythm, and verify its efficacy in simulations of uncoupled neural oscillators, and networks of coupled neural oscillators. Furthermore, we show that dithered stimulation can be implemented in neurostimulators with limited capabilities by toggling within a finite set of stimulation frequencies. SIGNIFICANCE: Likely implementable across a variety of existing brain stimulation devices, dithering-based selective entrainment has potential to enable new brain stimulation therapies, as well as new neuroscientific research exploiting its ability to modulate higher-order entrainment.
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spelling pubmed-76143232023-04-01 How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment Duchet, Benoit Sermon, James J Weerasinghe, Gihan Denison, Timothy Bogacz, Rafal J Neural Eng Article OBJECTIVE: While brain stimulation therapies such as deep brain stimulation for Parkinson’s disease (PD) can be effective, they have yet to reach their full potential across neurological disorders. Entraining neuronal rhythms using rhythmic brain stimulation has been suggested as a new therapeutic mechanism to restore neurotypical behaviour in conditions such as chronic pain, depression, and Alzheimer’s disease. However, theoretical and experimental evidence indicate that brain stimulation can also entrain neuronal rhythms at sub- and super-harmonics, far from the stimulation frequency. Crucially, these counterintuitive effects could be harmful to patients, for example by triggering debilitating involuntary movements in PD. We therefore seek a principled approach to selectively promote rhythms close to the stimulation frequency, while avoiding potential harmful effects by preventing entrainment at sub- and super-harmonics. APPROACH: Our open-loop approach to selective entrainment, dithered stimulation, consists in adding white noise to the stimulation period. MAIN RESULTS: We theoretically establish the ability of dithered stimulation to selectively entrain a given brain rhythm, and verify its efficacy in simulations of uncoupled neural oscillators, and networks of coupled neural oscillators. Furthermore, we show that dithered stimulation can be implemented in neurostimulators with limited capabilities by toggling within a finite set of stimulation frequencies. SIGNIFICANCE: Likely implementable across a variety of existing brain stimulation devices, dithering-based selective entrainment has potential to enable new brain stimulation therapies, as well as new neuroscientific research exploiting its ability to modulate higher-order entrainment. 2023-03-07 2023-03-07 /pmc/articles/PMC7614323/ /pubmed/36880684 http://dx.doi.org/10.1088/1741-2552/acbc4a Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Duchet, Benoit
Sermon, James J
Weerasinghe, Gihan
Denison, Timothy
Bogacz, Rafal
How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment
title How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment
title_full How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment
title_fullStr How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment
title_full_unstemmed How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment
title_short How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment
title_sort how to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614323/
https://www.ncbi.nlm.nih.gov/pubmed/36880684
http://dx.doi.org/10.1088/1741-2552/acbc4a
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