Cardiovascular Concentration-Effect Relationships of Amodiaquine and its Metabolite Desethylamodiaquine: Clinical and Pre-clinical Studies

BACKGROUND: Amodiaquine is a 4-aminoquinoline antimalarial used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Oral amodiaquine can cause bradycardia, hypotension, and electrocardiograph (ECG...

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Detalles Bibliográficos
Autores principales: Chan, Xin Hui S, Chotsiri, Palang, Capel, Rebecca A, Pike, James, Hanboonkunupakarn, Borimas, Lee, Sue J, Hanafiah, Maryam, Win, Yan Naung, Cremer, Maegan, Kiechel, Jean-René, Ogutu, Bernhards, Taylor, Walter RJ, Burton, Rebecca-Ann B, Tarning, Joel, White, Nicholas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614325/
https://www.ncbi.nlm.nih.gov/pubmed/36256474
http://dx.doi.org/10.1111/bcp.15569

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