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Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging
All-optical ultrasound (OpUS) is an emerging high resolution imaging paradigm utilising optical fibres. This allows both therapeutic and imaging modalities to be integrated into devices with dimensions small enough for minimally invasive surgical applications. Here we report a dual-modality fibre op...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614394/ https://www.ncbi.nlm.nih.gov/pubmed/37033302 http://dx.doi.org/10.1038/s44172-022-00020-9 |
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author | Zhang, Shaoyan Zhang, Edward Z. Beard, Paul C. Desjardins, Adrien E. Colchester, Richard J. |
author_facet | Zhang, Shaoyan Zhang, Edward Z. Beard, Paul C. Desjardins, Adrien E. Colchester, Richard J. |
author_sort | Zhang, Shaoyan |
collection | PubMed |
description | All-optical ultrasound (OpUS) is an emerging high resolution imaging paradigm utilising optical fibres. This allows both therapeutic and imaging modalities to be integrated into devices with dimensions small enough for minimally invasive surgical applications. Here we report a dual-modality fibre optic probe that synchronously performs laser ablation and real-time all-optical ultrasound imaging for ablation monitoring. The device comprises three optical fibres: one each for transmission and reception of ultrasound, and one for the delivery of laser light for ablation. The total device diameter is < 1 mm. Ablation monitoring was carried out on porcine liver and heart tissue ex vivo with ablation depth tracked using all-optical M-mode ultrasound imaging and lesion boundary identification using a segmentation algorithm. Ablation depths up to 2.1 mm were visualised with a good correspondence between the ultrasound depth measurements and visual inspection of the lesions using stereomicroscopy. This work demonstrates the potential for OpUS probes to guide minimally invasive ablation procedures in real time. |
format | Online Article Text |
id | pubmed-7614394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-76143942023-04-07 Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging Zhang, Shaoyan Zhang, Edward Z. Beard, Paul C. Desjardins, Adrien E. Colchester, Richard J. Commun Eng Article All-optical ultrasound (OpUS) is an emerging high resolution imaging paradigm utilising optical fibres. This allows both therapeutic and imaging modalities to be integrated into devices with dimensions small enough for minimally invasive surgical applications. Here we report a dual-modality fibre optic probe that synchronously performs laser ablation and real-time all-optical ultrasound imaging for ablation monitoring. The device comprises three optical fibres: one each for transmission and reception of ultrasound, and one for the delivery of laser light for ablation. The total device diameter is < 1 mm. Ablation monitoring was carried out on porcine liver and heart tissue ex vivo with ablation depth tracked using all-optical M-mode ultrasound imaging and lesion boundary identification using a segmentation algorithm. Ablation depths up to 2.1 mm were visualised with a good correspondence between the ultrasound depth measurements and visual inspection of the lesions using stereomicroscopy. This work demonstrates the potential for OpUS probes to guide minimally invasive ablation procedures in real time. 2022-07-28 /pmc/articles/PMC7614394/ /pubmed/37033302 http://dx.doi.org/10.1038/s44172-022-00020-9 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhang, Shaoyan Zhang, Edward Z. Beard, Paul C. Desjardins, Adrien E. Colchester, Richard J. Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging |
title | Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging |
title_full | Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging |
title_fullStr | Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging |
title_full_unstemmed | Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging |
title_short | Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging |
title_sort | dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614394/ https://www.ncbi.nlm.nih.gov/pubmed/37033302 http://dx.doi.org/10.1038/s44172-022-00020-9 |
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