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Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data
BACKGROUND: The full blood count (FBC) is a common blood test performed in general practice. It consists of many individual parameters that may change over time due to colorectal cancer. Such changes are likely missed in practice. We identified trends in these FBC parameters to facilitate early dete...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614427/ https://www.ncbi.nlm.nih.gov/pubmed/37056715 http://dx.doi.org/10.3310/nihropenres.13266.2 |
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author | Virdee, Pradeep S. Patnick, Julietta Watkinson, Peter Birks, Jacqueline Holt, Tim A. |
author_facet | Virdee, Pradeep S. Patnick, Julietta Watkinson, Peter Birks, Jacqueline Holt, Tim A. |
author_sort | Virdee, Pradeep S. |
collection | PubMed |
description | BACKGROUND: The full blood count (FBC) is a common blood test performed in general practice. It consists of many individual parameters that may change over time due to colorectal cancer. Such changes are likely missed in practice. We identified trends in these FBC parameters to facilitate early detection of colorectal cancer. METHODS: We performed a retrospective, case-control, longitudinal analysis of UK primary care patient data. LOWESS smoothing and mixed effects models were derived to compare trends in each FBC parameter between patients diagnosed and not diagnosed over a prior 10-year period. RESULTS: There were 399,405 males (2.3%, n = 9,255 diagnosed) and 540,544 females (1.5%, n = 8,153 diagnosed) in the study. There was no difference between cases and controls in FBC trends between 10 and four years before diagnosis. Within four years of diagnosis, trends in many FBC levels statistically significantly differed between cases and controls, including red blood cell count, haemoglobin, white blood cell count, and platelets (interaction between time and colorectal cancer presence: p <0.05). FBC trends were similar between Duke’s Stage A and D colorectal tumours, but started around one year earlier in Stage D diagnoses. CONCLUSIONS: Trends in FBC parameters are different between patients with and without colorectal cancer for up to four years prior to diagnosis. Such trends could help earlier identification. |
format | Online Article Text |
id | pubmed-7614427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-76144272023-04-12 Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data Virdee, Pradeep S. Patnick, Julietta Watkinson, Peter Birks, Jacqueline Holt, Tim A. NIHR Open Res Research Article BACKGROUND: The full blood count (FBC) is a common blood test performed in general practice. It consists of many individual parameters that may change over time due to colorectal cancer. Such changes are likely missed in practice. We identified trends in these FBC parameters to facilitate early detection of colorectal cancer. METHODS: We performed a retrospective, case-control, longitudinal analysis of UK primary care patient data. LOWESS smoothing and mixed effects models were derived to compare trends in each FBC parameter between patients diagnosed and not diagnosed over a prior 10-year period. RESULTS: There were 399,405 males (2.3%, n = 9,255 diagnosed) and 540,544 females (1.5%, n = 8,153 diagnosed) in the study. There was no difference between cases and controls in FBC trends between 10 and four years before diagnosis. Within four years of diagnosis, trends in many FBC levels statistically significantly differed between cases and controls, including red blood cell count, haemoglobin, white blood cell count, and platelets (interaction between time and colorectal cancer presence: p <0.05). FBC trends were similar between Duke’s Stage A and D colorectal tumours, but started around one year earlier in Stage D diagnoses. CONCLUSIONS: Trends in FBC parameters are different between patients with and without colorectal cancer for up to four years prior to diagnosis. Such trends could help earlier identification. F1000 Research Limited 2022-10-18 /pmc/articles/PMC7614427/ /pubmed/37056715 http://dx.doi.org/10.3310/nihropenres.13266.2 Text en Copyright: © 2022 Virdee PS et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Virdee, Pradeep S. Patnick, Julietta Watkinson, Peter Birks, Jacqueline Holt, Tim A. Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data |
title | Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data |
title_full | Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data |
title_fullStr | Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data |
title_full_unstemmed | Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data |
title_short | Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data |
title_sort | trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of uk primary care patient data |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614427/ https://www.ncbi.nlm.nih.gov/pubmed/37056715 http://dx.doi.org/10.3310/nihropenres.13266.2 |
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