Cargando…
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative diseases. Tau can be targeted using passively transferred antibodies (Abs) but the mechanisms of Ab protection are incompletely understood. Here we used a variety of cell and animal model systems and showed that th...
Autores principales: | Mukadam, Aamir S, Miller, Lauren VC, Smith, Annabel E, Vaysburd, Marina, Sakya, Siri A, Sanford, Sophie, Keeling, Sophie, Tuck, Benjamin J, Katsinelos, Taxiarchis, Green, Chris, Skov, Lise, Kaalund, Sanne S, Foss, Stian, Mayes, Keith, O’Connell, Kevin, Wing, Mark, Knox, Claire, Banbury, Jessica, Avezov, Edward, Rowe, James B, Goedert, Michel, Andersen, Jan Terje, James, Leo C, McEwan, William A |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614512/ https://www.ncbi.nlm.nih.gov/pubmed/36996217 http://dx.doi.org/10.1126/science.abn1366 |
Ejemplares similares
-
Cholesterol determines the cytosolic entry and seeded aggregation of tau
por: Tuck, Benjamin J., et al.
Publicado: (2022) -
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
por: Miller, Lauren V. C., et al.
Publicado: (2021) -
The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration
por: Katsinelos, Taxiarchis, et al.
Publicado: (2019) -
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
por: Dimou, Eleni, et al.
Publicado: (2023) -
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity
por: Caddy, Sarah L, et al.
Publicado: (2020)